I'm probably the only person on here familiar with Trenton.
There isn't much to be wary of in Trenton where you're going though, it's just kind of a dump in that area. Not at all dangerous. I'm guessing you aren't going to be coming through Trenton proper since Mufflex is right off 295. As long as you do that, you'll be fine.
Carlisle is probably more dangerous than the area you'll be in. You're also right next to
Grounds for Sculpture if you want to take in some culture or kill some time.